Announcement PDF ASX Announcement MAYNE PHARMA JEFFERIES GLOBAL HEALTHCARE CONFERENCE PRESENTATION 4 June 2026, Adelaide, Australia: Mayne Pharma Group Limited (Mayne Pharma or the Company)(ASX: MYX), today provides an investor presentation, to be given by the Company’s CEO Mr Aaron Gray to the Jefferies Global Healthcare Conference on 4 June 2026 in New York City. A copy of the presentation is attached. For further information contact: Dr Tom Duthy Investor Relations +61 402 493 727 ir@maynepharma.com Authorised for release to the ASX by the Board Chair Email Alerts To register for an email alert service to receive Mayne Pharma announcements released to the Australian Securities Exchange (ASX) please visit https://www.maynepharma.com/investor- relations/email-alerts/ Follow us on LinkedIn About Mayne Pharma Mayne Pharma is an ASX-listed specialty pharmaceutical company focused on commercialising novel pharmaceuticals, offering patients better, safe and more accessible medicines. Mayne Pharma is a leader in dermatology and women’s health in the United States and also provides contract development and manufacturing services to clients worldwide. Mayne Pharma has a 40- year track record of innovation and success in developing new oral drug delivery systems. These technologies have been successfully commercialised in numerous products that continue to be marketed around theworld. Tolearn more about MaynePharma, pleasevisit maynepharma.com. Mayne Pharma Group Limited Jefferies Global Healthcare Conference Presentation – New York Aaron Gray CEO 4 June 2026 (EDT) 2 Disclaimer The information provided is general in nature and is in summary form only. It is not complete and should be read in conjunction with the company’s audited Financial Statements and market disclosures. This material is not intended to be relied upon as advice to investors or potential investors. Non-IFRS information ● Other than as indicated, the financial information contained in this document is directly extracted or calculated from the audited Financial Statements. Throughout this document some non-IFRS financial information is stated, excluding certain specified income and expenses. Results excluding such items are considered by the Directors to provide a meaningful basis for comparison from period to period. ● Earnings before interest, tax, impairment, depreciation and amortisation (EBITDA) – a non-IFRS term – is considered by Directors to be a meaningful measure of the operating earnings and performance of the Group and this information may be useful for investors as it provides additional and relevant information that reflects the underlying performance of the business. ● The non-IFRS financial information has not been audited by the Group’s auditors. Forward looking statements ● This presentation contains forward-looking statements that involve subjective judgement and analysis and are subject to significant uncertainties, risks and contingencies, many of which are outside the control of, and are unknown to the Company. These forward looking statements use words such as ‘potential’, ‘expect’, ‘anticipate’, ‘intend’, ‘plan’ and ‘may’, and other words of similar meaning. No representation, warranty or assurance (express or implied) is given or made in relation to any forward looking statement by any person (including the Company). Actual future events may vary materially from the forward looking statements and the assumptions on which the forward looking statements are based. Given these uncertainties, readers are cautioned not to place undue reliance on such forward looking statements. Subject to the Company’s continuous disclosure obligations at law and under the listing rules of the Australian Securities Exchange, the Company disclaims any obligation to update or revise any forward looking statements. The factors that may affect the Company’s future performance include, among others: changes in economic conditions, changes in the legal and regulatory regimes in which the Company operates, litigation or government investigations, decisions by regulatory authorities, changes in behaviour of major customers, suppliers and competitors, interruptions to manufacturing or distribution, the success of research and development activities and research collaborations and the Company’s ability to protect its intellectual property. Other ● A glossary of industry terminology is contained in the Mayne Pharma Annual Report which can be accessed at maynepharma.com/investor-relations/results-reports and product descriptions are detailed at maynepharma.com/us-products and maynepharma.com/au-products. ● ACCUTANE®, ANNOVERA®, BIJUVA®, EPSOLAY®, IMVEXXY®, KADIAN®, NEXTSTELLIS® and TWYNEO® are trademarks of third parties. 3 International Dermatology A diversified portfolio of branded specialty and generic dermatology medicines including recently acquired products. Strategy to drive access and lower patient acquisition costs across rosacea, acne, psoriasis and atopic dermatitis. Strong focus on channel Disintermediation. Launch of DistributeRx in March 2026. Share price (ASX:MYX) A$2.33 / US$1.67 GICS Industry Group Code (Pharmaceuticals) 35202010 Shares on Issue 81.2 million Market Capitalisation A$189.2 / US$135.8 million FY25 Sales A$408.1 / US$289.8 million FY25 Underlying EBITDA A$47.0 / US$33.4 million Cash & Marketable Securities (31 Mar 2026) A$86.7 / US$61.6 million Top 20 Shareholders 57.5% Substantial Shareholders Mr Bruce Mathieson (6.5%) Funicular Funds LP (6.3% Rubric Capital Management LP (5.4%) Trium Capital LLP (5.0%) Analyst Coverage Madeleine Williams: Canaccord Genuity Andrew Goodsall: MST Marquee Snapshot Corporate Summary1,2,3 1. Share price data, Top 20 shareholders as at 1 June 2026 2. Financial data per Mayne Pharma 2025 Annual Report, FY25 / 1H FY26 / 3Q FY26 results 3. Assumes AUD/USD of $0.718 • Mayne Pharma is an ASX-listed specialty pharmaceutical company focused on commercialising novel pharmaceuticals, offering patients better, safe and more accessible medicines in Dermatology and Women’s Health • Mayne Pharma has a 40-year track record of innovation and success in developing new oral drug delivery systems. These technologies have been successfully commercialised in numerous products that continue to be marketed around the world Our Focus Segments Women’s Health A specialty branded portfolio with significant patent coverage focused on improving access and adherence in contraception and menopause care through targeted prescriber engagement and patient support. US Focus. Australian-based manufacturer (Salisbury, South Australia) with sales of branded and generic pharmaceutical products to customers and partners globally (ex-US) and the provision of contract development and manufacturing services to third party customers. Improving patient access to life-enhancing medications 4 Mayne Pharma in 2026 FY24 FY25 1H FY26 Branded Product Sales Now Represent a Significant Proportion (%) of Mayne Pharma’s Net Sales, Driving Margin Expansion 68% Branded │ 32% Generic 56% Gross Margin 79% Branded │ 21% Generic 61% Gross Margin 84% Branded │ 16% Generic 65% Gross Margin 500 bps 400 bps 68% 84% 79% 32% 21% 16% 5 Global Sales & Headcount Global footprint United States, A$339m, 83% Australia & NZ, A$42m, 10% Canada, A$20m, 5% Europe, A$4m, 1% Asia, A$3m, 1% FY25 Revenue by Region Headcount by Country1 Australia 244 employees United States 223 employees T O TA L H E A D C O U N T 467 Employees 1. As at 31 December 2025 Salisbury, South Australia Lexington, KY | Raleigh, NC TOTA L F Y 2 5 S A L E S A$408.1 million 6 FY25 Financial Highlights1 1. All numbers are expressed in AUD/A$ terms unless otherwise stated. 2. Underlying EBITDA is a non-IFRS measure and excludes earn-out reassessments, restructuring charges, class action settlement costs, derivative fair value adjustments and litigation expense. 3. Total net operating cashflow excluding tax refund, outflows for discontinued operations, and class action settlement. Earnout payments recognised as financing cash outflows. Revenue growth and targeted operating expenditure delivered 105% increase in underlying EBITDA versus the pcp A$408.1m Revenue up 5% FY24 60.6% Gross margin up from 56.3% FY24 A$47m Underlying EBITDA2 up 105% from A$22.9m FY24 A$109.7m Total direct segment contribution up 24% from A$88.5m FY24 A$45.4m Operating cashflow from continuing operations3 up 460% from A$8.1m FY24 A$100.4m Cash and marketable securities at 30 June 2025 down from A$149.3m FY24 7 A$178.4, 44% A$154.1, 38% A$75.6, 18% FY25 Snapshot - Segments A$109.7m  76% on pcp FY25 Total Direct Contribution A$62.0, 56% A$40.2, 37% A$7.4, 7% Women’s Health FY25 Segment Contribution (A$m, % of total) Dermatology International FY25 Revenue Contribution (A$m, % of total) 8 Mayne Pharma Disintermediation DistributeRx is Mayne Pharma's direct-to-patient distribution platform with Adelaide Apothecary serving as Mayne Pharma’s licensed pharmacy arm driving cash pay fulfilment of patient prescriptions as part of the Company’s overall disintermediation strategy. DistributeRx launched operations in March 2026 Disintermediation: Involves removing the intermediaries (wholesalers or others) between the manufacturer (Mayne Pharma) and the patient 59% Non-Wholesale volumes in 1H FY261 Corporate Structure Timeline 1. As a % percentage of total US Women’s Health and Dermatology product volumes 83% CAGR in US$ revenue since FY23 9 The US Pharmacy Distribution and Reimbursement System for Patient-Administered, Outpatient Brand-Name Drugs GPO= group purchasing organization; PSOA= pharmacy services administrative organization; DIR= direct and indirect remuneration; PBM= pharmacy benefit manager Source: Drug Channel’s Institute research. Chart illustrates flow for Patient-Administered, Outpatient Drugs. Please note that this chart is illustrative. It is not intended to be a complete representation of every type of product movement, financial flow, or contractual relationship in the marketplace. Product movement Financial flow Contract relationship • The path from manufacturer to patient is complex — and that complexity has real consequences. • Inefficient distribution, unpredictable pricing, and significant intermediary involvement create barriers at every step of the journey for manufacturers, clinicians, and patients alike. The Problem Manufacturer GPO Services contract Patient Third-party payer/ Health Plan Wholesale % Pass through of rebates and fees Reimbursement to PBM (including any network spread) PSAO Negotiation Services and data fees (specialty) Copayment or insurance Pharmacy Network participation Prescription Reimbursement Services agreement Rebates (DIR) & Fees Participation Participation Prime vendor agreement Pharmacy payment for product DIR Product shipment Product shipment Wholesaler payment for product Formulary agreement Dispense prescription Insurance premiums 10 Market Pressures In Action: Understanding The Roadblocks Unfilled Prescriptions High copays and complex prior authorizations cause patients to abandon prescriptions at the pharmacy counter Lost Profit Margin Rebates, DIR fees, and intermediary margins erode manufacturer profitability across the distribution chain Formulary Exclusions PBM restrictions limit formulary access, reducing branded product availability and patient choice Expanding Cash Market Patients increasingly bypass insurance, seeking lower-cost alternatives outside traditional channels Pharmacy Losses DIR clawbacks and below-cost reimbursement drive negative margins on branded dispensing Result: Patients lose access, manufacturers lose margin, and pharmacies lose viability — creating a cycle of inefficiency The complexity of the US pharmacy distribution system creates barriers that impact manufacturers, pharmacies, and patients 11 Mayne Pharma Model to Support Efficiency & Profitability Manufacturers Pharmacy Patients The Mayne Pharma approach is simple, efficient, and direct: • Simple — Fewer intermediaries mean clearer pricing for clinicians and more consistent access to therapy for patients. • Efficient — Streamlined distribution reduces friction across the product lifecycle, improving gross-to-net results for manufacturers. • Direct — Medications reach patients faster, with transparent pricing and fewer delays in care. The Solution 12 Disintermediation – What are the benefits? Patient Benefits Manufacturer Benefits Inventory – tighter controls and lower returns Stronger negotiating position with spec pharmacy v wholesale Less intermediaries drives lower fees in totality Transparent and predictable costs Greater certainty on co-pay arrangements Higher rates of fulfilment (pharmacy or direct) Simpler for prescription repeats = higher compliance Improved Gross to Net Sales Improved Product Gross Margins Outcomes for Mayne Pharma For example: 13 DistributeRx partners with manufacturers, providers, and pharmacies to improve patient access and offer predictable prices • Currently, 31 Mayne Pharma + 178 non-Mayne Pharma dermatology products offered • All Mayne Pharma Dermatology sales reps fully onboarded to DistributeRx • New strategic focus on selling the advantages of DistributeRx for manufacturers, prescribers and their patients of this healthcare ecosystem, relative to individual portfolio products • Streamlining how therapies move from manufacturer to patient • Delivering the strategies, tools, and services that ensure patients can start and stay on the therapies they need • ePharmacy size ~US$252 billion by 2030 (CAGR 17%)1 driven by rising consumer adoption of digital pharmacy and home delivery PRESCRIPTION ACCESS MADE SIMPLE 1. Precedence Research 14 DistributeRx Launch Metrics for Initial Month of March 2026 +72% Versus internal prescription (Rx) forecast +92% Rx growth versus the pcp (March 2025) +73% Rx growth versus pre-launch prescription volumes (Feb) ~6,400 Total Rx March 2026 ~1,600 New prescribers added since launch ~70% Of targeted salesforce headcount for Q3 FY26 • Initial DistributeRx launch exceeded expectations, delivery very strong growth in March versus forecast, prior month and pcp • Strong demand profile: May 2026 announced major expansion of Adelaide Apothecary (MYX cash pay pharmacy) in Lexington, KY • Up to 2.5m Rx per annum capacity, US$4m CAPEX across two phases for equipment and automation capability 15 DistributeRx Solution Versus Competitive Set FEATURE DISTRIBUTERx NATIONAL HUBS (BLINKRx, PHILRx) AMAZON PHARMACY MARK CUBAN COST + DRUGS INDEPENDENT PHARMACIES Prescription Fulfillment Home Delivery LIMITED Prior Authorization Support PARTIAL PARTIAL Wholly Owned Cash Pharmacy Price Transparency PARTIAL Dermatology Expertise Insurance Independence PARTIAL National Scalability 16 3Q FY26 Financial Results1 1. All numbers are expressed in AUD/A$ terms unless otherwise stated and are unaudited 2. Underlying EBITDA is a non-IFRS measure and excludes earn-out reassessments, litigation and restructuring charges, derivative fair value adjustments, other 3. Total net operating cashflow excluding outflows for discontinued operations and legal expenses (Scheme). Earnout payments recognised as financing cash outflows 3Q FY26 delivered resilient earnings, with margin discipline underpinning performance A$85.2m Revenue up 1% from 3Q FY25 63% Gross margin up from 59% 3Q FY25 -A$1.4m Underlying EBITDA2 up 57% from 3Q FY25 A$17.9m Total direct segment contribution up 11% from 3Q FY25 A$28.3m Adjusted operating cashflow from continuing operations3 up 90% from 3Q FY25 A$86.7m Cash and marketable securities at 31 Mar 2026 up 29% from 31 Dec 2025 17 FY26 Highlights Year to Date Women’s Health Dermatology • Strong portfolio momentum with sustained demand and share gains; NEXTSTELLIS®, BIJUVA® and IMVEXXY® demand hit record highs in Dec 2025 • FDA removal of “Black Box” warning from BIJUVA® label – one of only six menopausal products to have boxed warning updated • Menopause awareness driving strong market growth, positive tailwinds for BIJUVA® and IMVEXXY® • Improved prescriber engagement cadence and effectiveness, focused on improving patient access and coverage to drive higher fill rates • Investing for future growth, focused on increasing share of voice and converting demand more efficiently International • Channel disintermediation at scale: >70% of Mayne Pharma Rx outside the traditional channel with ongoing mix/price management • TWYNEO® and EPSOLAY® acquired and launched in Q1 FY26; TWYNEO® achieved better-than-expected commercial formulary coverage • Adelaide Apothecary direct-to-patient revenues grew 63% pcp; DistributeRx launched in March 2026 with strong initial results • Strong Rx growth in generic ACCUTANE® driven by strategic digital health partnership specialising in dermatology • NEXTSTELLIS® PBS approval in Australia driving strong sales growth; 118% growth in 3-pack volumes Dec 2025 (post PBS) vs Jul 2025 (pre PBS) • Salisbury facility A$18m upgrade completed (incl. A$4.8M MMI government grant); exploring new global partnerships for product manufacturing • Strong KADIAN® sales growth in Canada following expanded distribution agreement • External recognition: finalist in the 2025 Australian Export Awards and multiple SA Premier’s Business & Export Awards (incl. SA Business of the Year) 18 Future Growth Drivers Women’s Health Dermatology • Drive Market Penetration – increase low single digit market share + solid market growth • Portfolio economics – long-dated patent life to protect value, support pricing power, and sustain investment • Commercial execution – upgraded marketing, optimised field-force effectiveness, tighter targeting of high-value prescribers • Improving Access – payer contracting and patient access programs to reduce pharmacy friction and drive higher fill rates International • Scale disintermediation – specialty pharmacy ecosystem to reduce friction and lift direct contribution as mix improves: DistributeRx • Expand portfolio – capital-efficient BD and targeted acquisitions of new FDA-approved brands to broaden addressable segments • Drive Rx growth – stronger commercial execution, sales force upgrades, and refreshed marketing to accelerate demand • Improve margins – through product mix and channel shift towards higher-value brands and more favourable channel economics • Salisbury capacity – post-upgrade enabling higher output, better service levels, and improved DIFOT to support export growth • NEXTSTELLIS® PBS – listing tailwind driving Australian Rx growth as affordability and access improves • Operating leverage – unlock value from significant infrastructure investment and improved facility utilisation • Expanded partnerships – international supply agreements to grow exports and increase third-party volume through the network 19 Recent M&A Activity in Women’s Health & Dermatology Women’s Health Dermatology US$11.75B Sun Pharma → Organon Apr 2026 | Largest pharma deal of 2026. Creates top-3 global women’s health player with 70+ products across 140 countries. Also enters biosimilars as 7th largest global player. US$18.3B Blackstone/TPG → Hologic Oct 2025 (closed Apr 2026) | Take-private of global women’s health medtech leader. 46% premium. Includes breast health, diagnostics, and gynecological surgical products. Up to US$1.2B Organon → Dermavant Oct 2024 | Adds VTAMA (tapinarof) for plaque psoriasis and atopic dermatitis. US$175m upfront + US$75m regulatory + US$950m commercial milestones. US$1.3B J&J → Yellow Jersey Therapeutics May 2024 | Atopic dermatitis pipeline acquisition. Adds novel biologic candidates to J&J’s immunology portfolio. Women’s Health and Dermatology are among the most active M&A sectors in pharma — validating the strategic value of specialty portfolios in these therapeutic areas Sources: Company announcements, Fierce Pharma, DealForma, PitchBook. Deal values as announced; may include contingent payments. 20 FY26 outlook Mayne Pharma's strategic priorities are focused on driving sustainable growth across its Women's Health and Dermatology segments through dedicated commercial investment, refreshed marketing, and the continued build-out of the DistributeRx ecosystem, while actively unlocking value from International investments including the NEXTSTELLIS® PBS listing in Australia and expanded supply agreements. The Company continues to examine capital allocation strategies, which may include an on-market share buy- back while pursuing synergistic and capital-efficient business development opportunities. You deserve tomorrow. For further information contact: Dr Tom Duthy Investor Relations +61 402 493 727 ir@maynepharma.com To register for an email alert service to receive Mayne Pharma announcements released to the Australian Securities Exchange (ASX) please visit https://www.maynepharma.com/investor-relations/email-alerts/ Follow us on LinkedIn Appendix 23 Earn-Out and Deferred Consideration Liabilities - Update Dermatology Women’s Health International 8% Net Sales on all TXMD Licensed Products (ANNOVERA®, IMVEXXY®, BIJUVA®) N/M2 N/M Royalties Milestones 10% Net Sales to Population Council (ANNOVERA®)1 Population Council: US$40.0m (cumulative sales of US$400m: ANNOVERA®) Population Council: US$40.0m (cumulative sales of US$1.0bn: ANNOVERA®) N/M 1. The 10% royalty is deducted from Net Sales of ANNOVERA® prior to the application of the 8% royalty payable to TXMD 2. N/M – not material N/M TXMD: US$100m in net revenue (US$5m milestone payment) TXMD: US$200m in net revenue (US$10m milestone payment) TXMD: US$300m in net revenue (US$15m milestone payment) Variable COGS payment to Gedeon Richter (GR) (formerly Mithra) (NEXTSTELLIS®) (Embedded in gross margin) Dependent on forward sales of NEXTSTELLIS® (no guidance provided) Contingent consideration represents the estimated present value of the future royalties and milestones payable on net sales of the product Carrying Value FY25 FY24 Current $26.6m $33.2m Non-Current $371.4m $329.6m 24 Orange Book Listed Patents – Major Branded Dermatology Women’s Health Last Patent Expiry 2043 2039 2034* 2032 Last Patent Expiry 2035** 2030 2039 2034 Source: Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations. * Paragraph IV challenges for IMVEXXY® brought by Sun Pharma and Teva. ** Potential RHOFADE® generic from 2026 (pending approval) 2041 2041